Most of the major plot changes the series (Spoilers)
- The girls look like normal Japanese girls before they tranform
- Minako Aino is a pop idol, rather than being a normal schoolgirl like the other girls. She is also more serious and strict than in the other incarnations where she is cheerful and funny
- Minako also dies in the end of the series because of a illness
- The Game Center Crown has become a karaoke parlor
- Motoki changes from an attractive, cool character to a socially awkward, crazed turtle fan.
- Luna and Artemis are plush toys rather than real cats.
- Luna becomes a Sailor Soldier, known as Sailor Luna
- Mio Kuroki is a younger, shadow version of Queen Beryl is added.
- Sailor Mercury turns evil and becomes Dark Mercury
- Sailor Moon has an upgraded form, known as Princess Sailor Moon. However, Princess Serenity had full control of it
- Nephrite is killed by Queen Beryl, but is revived and is forced to work at Crown towards the end of the series
- It's hinted that Nephrite and Ami have crushes on each other
- The Shitennou are alive for most of the series and all have their own agendas
- Princess Serenity is the one who destroys the Earth